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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EN2
All Species:
9.7
Human Site:
S126
Identified Species:
17.78
UniProt:
P19622
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19622
NP_001418.2
333
34211
S126
E
Q
L
L
G
S
G
S
R
E
P
R
Q
N
P
Chimpanzee
Pan troglodytes
XP_001146034
399
41238
S192
E
Q
L
L
G
S
G
S
R
E
P
R
Q
N
P
Rhesus Macaque
Macaca mulatta
XP_001106130
334
34311
S127
E
Q
L
L
G
S
G
S
Q
E
P
R
Q
N
P
Dog
Lupus familis
XP_854121
247
25817
G58
D
A
V
G
P
L
D
G
A
L
K
A
R
A
L
Cat
Felis silvestris
Mouse
Mus musculus
P09066
324
33799
E119
E
Q
L
L
G
A
R
E
S
R
P
N
P
A
C
Rat
Rattus norvegicus
NP_001102684
323
33670
E118
E
Q
I
L
G
A
R
E
S
R
P
N
P
A
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512614
188
20519
Chicken
Gallus gallus
Q05917
288
30431
P92
P
A
A
A
A
P
A
P
G
A
P
V
P
G
G
Frog
Xenopus laevis
P52729
265
29878
T72
E
L
Y
T
E
R
D
T
G
A
L
S
G
A
E
Zebra Danio
Brachydanio rerio
P31533
261
29466
R72
N
I
V
E
R
E
N
R
C
P
S
A
P
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02836
552
59392
E136
Q
T
H
T
T
N
E
E
E
E
A
E
E
D
D
Honey Bee
Apis mellifera
P09076
109
12608
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_794753
249
28228
A60
G
S
R
K
P
S
K
A
H
H
R
K
E
D
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
73.1
98.1
46.2
N.A.
86.7
86.7
N.A.
48.9
66
57.3
56.1
N.A.
27.5
22.8
N.A.
38.7
Protein Similarity:
100
75.1
99
50.7
N.A.
87.9
88.5
N.A.
52.2
70.5
64.8
63.3
N.A.
37.3
27.3
N.A.
51.3
P-Site Identity:
100
100
93.3
0
N.A.
40
33.3
N.A.
0
6.6
6.6
0
N.A.
6.6
0
N.A.
6.6
P-Site Similarity:
100
100
100
20
N.A.
46.6
46.6
N.A.
0
6.6
13.3
6.6
N.A.
33.3
0
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
8
8
8
16
8
8
8
16
8
16
0
31
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
16
% C
% Asp:
8
0
0
0
0
0
16
0
0
0
0
0
0
16
8
% D
% Glu:
47
0
0
8
8
8
8
24
8
31
0
8
16
0
16
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
8
39
0
24
8
16
0
0
0
8
16
8
% G
% His:
0
0
8
0
0
0
0
0
8
8
0
0
0
0
0
% H
% Ile:
0
8
8
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
8
0
0
8
0
0
0
8
8
0
0
0
% K
% Leu:
0
8
31
39
0
8
0
0
0
8
8
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
8
8
0
0
0
0
16
0
24
0
% N
% Pro:
8
0
0
0
16
8
0
8
0
8
47
0
31
0
24
% P
% Gln:
8
39
0
0
0
0
0
0
8
0
0
0
24
0
0
% Q
% Arg:
0
0
8
0
8
8
16
8
16
16
8
24
8
0
0
% R
% Ser:
0
8
0
0
0
31
0
24
16
0
8
8
0
0
8
% S
% Thr:
0
8
0
16
8
0
0
8
0
0
0
0
0
0
0
% T
% Val:
0
0
16
0
0
0
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _